Project Description

Enterococcus faecalis (E. faecalis) is a Gram-positive bacterium, which is presently amongst the most prevalent multidrug resistant hospital pathogens. Its ability to develop quorum sensing (QS)-mediated biofilms further exacerbates its pathogenicity and triggers life-threatening infections. Therefore, developing a suitable remedy for curing E. faecalis-mediated enterococcal infections is an arduous task.Sortase family proteins play an essential role in biofilm formation by E. faecalis. Till now three-dimensional structure of none of the sortase family proteins is known from E. faecalis. Our study will provide the complete understanding of sortase family proteins and subsequently biofilm formation leading to inhibitor identification and validation.