Project Description

The emergence of the novel coronavirus in Wuhan, Hubei Province, China, in December 2019 marked the synchronization of the world to a peculiar clock that is counting infected cases and deaths instead of hours and minutes. The pandemic, highly transmissible severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has indeed caused considerable morbidity and mortality and drastically changed our everyday lives. This study will employ blood samples from COVID-19 patients to understand the differential gene expression and genetic profiling of disease-associated ACE2 genes, to provide molecular insights into COVID-19 affected patients. Knowledge, analysis, and changes in the transcriptome and genetic profile in COVID-19 affect patients in India are significantly underexplored. A broader understanding would help anticipate potential mechanisms involved in the individuals via NGS and transcriptomics analysis. Concretely, the results are expected to provide a platform for understanding the molecular pathology of COVID-19 patients. The novel findings may provide insight into changes in the transcriptomics and genetic profile of COVID19 affected the Indian population.